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In the days and weeks following the procedure cheap hydrea 500mg fast delivery, the radiation emitted from the seeds destroys the vessels and directly kills the tumor cells in the vicinity of the treatment order 500mg hydrea with amex. Rather generic 500 mg hydrea visa, they are constantly reacting with other atoms to form and to break down more complex substances. Although electrons do not follow rigid orbits a set distance away from the atom’s nucleus, they do tend to stay within certain regions of space called electron shells. The atoms of the elements found in the human body have from one to five electron shells, and all electron shells hold eight electrons except the first shell, which can only hold two. If you take a look at the periodic table of the elements, you will notice that hydrogen and helium are placed alone on either sides of the top row; they are the only elements that have just one electron shell (Figure 2. Again, a look at the periodic table reveals that all of the elements in the second row, from lithium to neon, have just two electron shells. The factor that most strongly governs the tendency of an atom to participate in chemical reactions is the number of electrons in its valence shell. If the valence shell is full, the atom is stable; meaning its electrons are unlikely to be pulled away from the nucleus by the electrical charge of other atoms. If the valence shell is not full, the atom is reactive; meaning it will tend to react with other atoms in ways that make the valence shell full. This single electron is likely to be drawn into This OpenStax book is available for free at http://cnx. All atoms (except hydrogen and helium with their single electron shells) are most stable when there are exactly eight electrons in their valence shell. This principle is referred to as the octet rule, and it states that an atom will give up, gain, or share electrons with another atom so that it ends up with eight electrons in its own valence shell. For example, oxygen, with six electrons in its valence shell, is likely to react with other atoms in a way that results in the addition of two electrons to oxygen’s valence shell, bringing the number to eight. When two hydrogen atoms each share their single electron with oxygen, covalent bonds are formed, resulting in a molecule of water, H O. In so doing, the two elements form the simplest of organic molecules, methane, which also is one of the most abundant and stable carbon-containing compounds on Earth. Incidentally, the name “hydrogen” reflects its contribution to water (hydro- =2 “water”; -gen = “maker”). Most physicists would say no, because the negatively charged electrons in their valence shells repel one another. No force within the human body—or anywhere in the natural world—is strong enough to overcome this electrical repulsion. So when you read about atoms linking together or colliding, bear in mind that the atoms are not merging in a physical sense. The new grouping is typically more stable—less likely to react again—than its component atoms were when they were separate. A more or less stable grouping of two or more atoms held together by chemical bonds is called a molecule. The bonded atoms may be of the same element, as in the case of H , which is called molecular hydrogen or hydrogen gas. Ions and Ionic Bonds Recall that an atom typically has the same number of positively charged protons and negatively charged electrons. But when an atom participates in a chemical reaction that results in the donation or acceptance of one or more electrons, the atom will then become positively or negatively charged. This happens frequently for most atoms in order to have a full valence shell, as described previously. This can happen either by gaining electrons to fill a shell that is more than half-full, or by giving away electrons to empty a shell than is less than half-full, thereby leaving the next smaller electron shell as the new, full, valence shell. What happens to the charged electroscope when a conductor is moved between its plastic sheets, and why? This characteristic makes potassium highly likely to participate in chemical reactions in which it donates one electron. Thus, it is highly likely to bond with other atoms in such a way that fluorine accepts one electron (it is easier for fluorine to gain one electron than to donate seven electrons). When it does, its electrons will outnumber its protons by – one, and it will have an overall negative charge. Atoms that have more than one electron to donate or accept will end up with stronger positive or negative charges. The opposite charges of cations and anions exert a moderately strong mutual attraction that keeps the atoms in close proximity forming an ionic bond. Water is an essential component of life because it is able to break the ionic bonds in salts to free the ions. The electrical activity that derives from the interactions of the charged ions is why they are also called electrolytes. Covalent Bonds Unlike ionic bonds formed by the attraction between a cation’s positive charge and an anion’s negative charge, molecules formed by a covalent bond share electrons in a mutually stabilizing relationship. Like next-door neighbors whose kids hang out first at one home and then at the other, the atoms do not lose or gain electrons permanently. Instead, the electrons move 52 Chapter 2 | The Chemical Level of Organization back and forth between the elements. Because of the close sharing of pairs of electrons (one electron from each of two atoms), covalent bonds are stronger than ionic bonds. Notice that the two covalently bonded atoms typically share just one or two electron pairs, though larger sharings are possible. The important concept to take from this is that in covalent bonds, electrons in the outermost valence shell are shared to fill the valence shells of both atoms, ultimately stabilizing both of the atoms involved. In a single covalent bond, a single electron is shared between two atoms, while in a double covalent bond, two pairs of electrons are shared between two atoms. The sharing of the negative electrons is relatively equal, as is the electrical pull of the positive protons in the nucleus of the atoms involved. This is why covalently bonded molecules that are electrically balanced in this way are described as nonpolar; that is, no region of the molecule is either more positive or more negative than any other. Polar Covalent Bonds Groups of legislators with completely opposite views on a particular issue are often described as “polarized” by news writers. In chemistry, a polar molecule is a molecule that contains regions that have opposite electrical charges. The molecule has three parts: one atom of oxygen, the nucleus of which contains eight protons, and two hydrogen atoms, whose nuclei each contain only one proton. Because every proton exerts an identical positive charge, a nucleus that contains eight protons exerts a charge eight times greater than a nucleus that contains one proton. This means that the negatively charged electrons present in the water molecule are more strongly attracted to the oxygen nucleus than to the hydrogen nuclei.

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Pharmacokinetics: 10 to 20 percent of the active compound reaches the lungs order 500mg hydrea visa, the rest is deposited in the oropharynx buy hydrea online. Warning: zanamivir is not recommended for the treatment of patients with under- lying airways disease (such as asthma or chronic obstructive pulmonary disease) hydrea 500 mg otc. Interactions: no clinically significant pharmacokinetic drug interactions are pre- dicted based on data from in vitro studies. Side effects: zanamivir has a good safety profile and the overall risk for any respi- ratory event is low. Patient information: the use of zanamivir for the treatment of influenza has not been shown to reduce the risk of transmission of influenza to others. There is a risk of bronchospasm, especially in the setting of underlying airways disease, and patients should stop zanamivir and contact their physician if they expe- rience increased respiratory symptoms during treatment such as worsening wheez- ing, shortness of breath, or other signs or symptoms of bronchospasm. A patient with asthma or chronic obstructive pulmonary disease must be made aware of the risks and should have a fast-acting bronchodilator available. Patients scheduled to take inhaled bronchodilators at the same time as zanamivir should be advised to use their bronchodilators before taking zanamivir. Safety and efficacy of intravenous zanamivir in preventing experimental human influenza A virus infection. Pharmacokinetics of zanamivir after intravenous, oral, inhaled or intranasal administration to healthy volunteers. Comparison of elderly peo- ple´s technique in using two dry powder inhalers to deliver zanamivir: randomised con- trolled trial. Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenzavirus infections. Zanamivir for treatment of symptomatic influenza A and B infection in children five to twelve years of age: a randomized controlled trial. Impact of zanamivir on antibi- otic use for respiratory events following acute influenza in adolescents and adults. Zanamivir for the treatment of influenza A and B infection in high-risk patients: a pooled analysis of randomized controlled trials. Efficacy of zanamivir against avian influenza A viruses that possess genes encoding H5N1 internal proteins and are pathogenic in mammals. Risk for respiratory events in a cohort of patients receiving inhaled zanamivir: a retrospective study. Zanamivir is an effec- tive treatment for influenza in children undergoing therapy for acute lymphoblastic leu- kemia. Neuraminidase sequence analysis and susceptibilities of influenza virus clinical isolates to zanamivir and oseltamivir. Zanamivir prophylaxis: an effective strategy for the prevention of influenza types A and B within households. Randomized, placebo-controlled studies of inhaled zanamivir in the treatment of influenza A and B: pooled efficacy analysis. The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor. Three-dimensional structure of the complex of 4- guanidino-Neu5Ac2en and influenza virus neuraminidase. Coadministration of orally inhaled zanamivir with inactivated trivalent influenza vaccine does not adversely affect the pro- duction of antihaemagglutinin antibodies in the serum of healthy volunteers. Neuraminidase inhibitor-resistant influenza viruses may differ substantially in fitness and transmissibility. It highlights continued of malaria decreases through much of sub-Saharan Africa, the need progress made towards meeting international targets for malaria to diferentiate malaria from non-malarial fevers becomes more control to be achieved by 2010 and 2015. A small number of countries have shown that it is possible to scale up rapidly the availability of malaria diag- International funding for malaria control has risen steeply in the nostic testing on a national scale, provided that attention is given to past decade. These fgures represent a substantial increase have been delivered to sub-Saharan Africa, enough to cover 76% of since 2005, when only 5 countries were providing sufcient courses the 765 million persons at risk of malaria. Nets delivered in 2006 and 2007 are therefore already few decades has led to an intensifcation of efcacy monitoring to due for replacement, and those delivered between 2008 and 2010 allow early detection of resistance. Failure to replace these nets could lead to a resurgence in parasite sensitivity to artemisinins, the clinical and parasitological of malaria cases and deaths. The widespread use of a single class of insecticide 2000 and 2009 was found in 32 of the 56 malaria-endemic countries increases the risk that mosquitoes will develop resistance, which outside Africa, while downward trends of 25%–50% were seen in 8 could rapidly lead to a major public health problem. It is estimated that the number of cases of malaria rose from 233 million in 2000 to 244 million in 2005 but decreased to 225 million in 2009. The number of deaths due to malaria is estimated to have decreased from 985 000 in 2000 to 781 000 in 2009. While progress in reducing the malaria burden has been remark- able, there was evidence of an increase in malaria cases in 3 countries in 2009 (Rwanda, Sao Tome and Principe, and Zambia). The increases in malaria cases highlight the fragility of malaria control and the need to maintain control programmes even if numbers of cases have been reduced substantially. The experiences in Rwanda and Zambia also indicate that monthly monitoring of disease surveillance data, both nationally and subnationally, is essential. Since many countries in sub-Saharan Africa had inadequate data to monitor disease trends, it is apparent that greater eforts need to be made to strengthen routine surveillance systems. Major epidemiological events could be occurring in additional countries without being detected and inves- tigated. On World Malaria Day 2008, the United Nations Secretary-Gen- countries in other Regions reported having a policy of parasito- eral called for eforts to ensure universal coverage with malaria logical testing of suspected malaria cases in persons of all ages, prevention and treatment programmes by the end of 2010. By November 2010, 25 countries were still allowing the marketing of  Policies and strategies for malaria control these products (down from 37 in 2009) and 39 pharmaceutical To attain the 2010 and 2015 targets, countries must reach all companies were manufacturing them. Spending by national governments on malaria transmission by vector control in all epidemiological settings. Of 106 malaria-endemic countries and areas, 77 received external quences, particularly pregnant women and infants. External fnancing appears to be Guinea, in the Western Pacifc Region, also adopted this policy concentrated on programme activities, particularly the procure- in 2009. The widespread use of a single class of insecticide to larger amounts of external fnancing, government fnancing increases the risk that mosquitoes will develop resistance, which exceeds that of external fnancing in countries in the pre-elimi- could rapidly lead to a major public health problem, particularly nation and elimination stages. The percentage of pregnant women who received the second 2010, sufcient to cover a further 10% of the population at risk. A model-based estimate showed that 42% of African households primarily to low coverage rates in Nigeria. There is no diference ularly in the African Region (from 26% to 35%), Eastern Mediterra- in usage rates between female and male children < 5 years of age nean Region (47% to 68%) and South-East Asia Region excluding (ratio girls: boys = 0. Data which corresponds to protection for 10% of the population at risk from a limited number of countries suggest that both microscopy in 2009. In 2009, the than fve-fold, and the total number of tests carried out (micros- European Region reported no cases of P. By combining household survey data with health facility data it be given to countries which harbour most of the malaria burden can be estimated that, on average, 65% of treatment needs are outside Africa. There were 8 countries in the pre-elimination stage of malaria are more difcult to construct for patients who are treated in the control in 2009 and 10 countries are implementing elimina- private sector, but household surveys indicate febrile patients tion programmes nationwide (8 having entered the elimina- treated in the private sector are 25% less likely to receive an anti- tion phase in 2008).

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The glial cell is wrapped around the axon several times with little to no cytoplasm between the glial cell layers hydrea 500mg cheap. For oligodendrocytes buy generic hydrea 500 mg online, the rest of the cell is separate from the myelin sheath as a cell process extends back toward the cell body purchase hydrea american express. For Schwann cells, the outermost layer of the cell membrane contains cytoplasm and the nucleus of the cell as a bulge on one side of the myelin sheath. The inner edge wraps around the axon, creating several layers, and the other edge closes around the outside so that the axon is completely enclosed. The axon contains microtubules and neurofilaments that are bounded by a plasma membrane known as the axolemma. Outside the plasma membrane of the axon is the myelin sheath, which is composed of the tightly wrapped plasma membrane of a Schwann cell. What aspects of the cells in this image react with the stain to make them a deep, dark, black color, such as the multiple layers that are the myelin sheath? Because a micrometer is 1/1000 of a millimeter, this means that the length of a myelin sheath can be 100–1000 times the diameter of the axon. If the myelin sheath were drawn to scale, the neuron would have to be immense—possibly covering an entire wall of the room in which you are sitting. The causes of these diseases are not the same; some have genetic causes, some are caused by pathogens, and others are the result of autoimmune disorders. The antibodies produced by lymphocytes (a type of white blood cell) mark myelin as something that should not be in the body. This is where the name of the disease comes from; sclerosis means hardening of tissue, which is what a scar is. Sensory symptoms or motor deficits are common, and autonomic failures can lead to changes in the heart rhythm or a drop in blood pressure, especially when standing, which causes dizziness. Before getting to the nuts and bolts of how this works, an illustration of how the components come together will be helpful. The contact is a synapse where another graded potential is caused by the release of a chemical signal from the axon terminals. The target of the upper motor neuron is the dendrites of the lower motor neuron in the gray matter of the spinal cord. What happens next depends on how your nervous system interacts with the stimulus of the water temperature and what you do in response to that stimulus. Found in the skin of your fingers or toes is a type of sensory receptor that is sensitive to temperature, called a thermoreceptor. If the stimulus is strong, the voltage of the cell membrane will change enough to generate an electrical signal that will travel down the axon. You have learned about this type of signaling before, with respect to the interaction of nerves and muscles at the neuromuscular junction. The voltage at which such a signal is generated is called the threshold, and the resulting electrical signal is called an action potential. In this example, the action potential travels—a process known as propagation—along the axon from the axon hillock to the axon terminals and into the synaptic end bulbs. When this signal reaches the end bulbs, it causes the release of a signaling molecule called a neurotransmitter. The neurotransmitter diffuses across the short distance of the synapse and binds to a receptor protein of the target neuron. When the molecular signal binds to the receptor, the cell membrane of the target neuron changes its electrical state and a new graded potential begins. If that graded potential is strong enough to reach threshold, the second neuron generates an action potential at its axon hillock. The thalamus then sends the sensory information to the cerebral cortex, the outermost layer of gray matter in the brain, where conscious perception of that water temperature begins. Finally, a plan is developed about what to do, whether that is to turn the temperature up, turn the whole shower off and go back to bed, or step into the shower. To do any of these things, the cerebral cortex has to send a command out to your body to move muscles (Figure 12. The upper motor neuron is in this region, called the precentral gyrus of the frontal cortex, which has an axon that extends all the way down the spinal cord. At the level of the spinal cord at which this axon makes a synapse, a graded potential occurs in the cell membrane of a lower motor neuron. Acetylcholine is released at this specialized synapse, which causes the muscle action potential to begin, following a large potential known as an end plate potential. All of this occurs in a fraction of a second, but this story is the basis of how the nervous system functions. The career path of a research scientist can be straightforward: college, graduate school, postdoctoral research, academic research position at a university. A Bachelor’s degree in science will get you started, and for neurophysiology that might be in biology, psychology, computer science, engineering, or neuroscience. There are many different programs out there to study the nervous system, not just neuroscience itself. These are usually considered five-year programs, with the first two years dedicated to course work and finding a research mentor, and the last three years dedicated to finding a research topic and pursuing that with a near single-mindedness. The research will usually result in a few publications in scientific journals, which will make up the bulk of a doctoral dissertation. In this position, a researcher starts to establish their own research career with the hopes of finding an academic position at a research university. Especially for neurophysiology, a medical degree might be more suitable so you can learn about the clinical applications of neurophysiology and possibly work with human subjects. Biotechnology firms are eager to find motivated scientists ready to tackle the tough questions about how the nervous system works so that therapeutic chemicals can be tested on some of the most challenging disorders such as Alzheimer’s disease or Parkinson’s disease, or spinal cord injury. Others with a medical degree and a specialization in neuroscience go on to work directly with patients, diagnosing and treating mental disorders. You can do this as a psychiatrist, a neuropsychologist, a neuroscience nurse, or a neurodiagnostic technician, among other possible career paths. To understand how neurons are able to communicate, it is necessary to describe the role of an excitable membrane in generating these signals. The basis of this communication is the action potential, which demonstrates how changes in the membrane can constitute a signal. Looking at the way these signals work in more variable circumstances involves a look at graded potentials, which will be covered in the next section. Electrically Active Cell Membranes Most cells in the body make use of charged particles, ions, to build up a charge across the cell membrane. For skeletal muscles to contract, based on excitation–contraction coupling, requires input from a neuron. Both of the cells make use of the cell membrane to regulate ion movement between the extracellular fluid and cytosol. As you learned in the chapter on cells, the cell membrane is primarily responsible for regulating what can cross the 524 Chapter 12 | The Nervous System and Nervous Tissue membrane and what stays on only one side.